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1,363 results on '"Klotz L"'

1. Proportion of Gleason 8-10 prostate cancer found on biopsy and tumor aggressiveness in matched cohorts of men in Asia and Western countries

Author

Dong, L., primary, Lajkosz, K., additional, Sanchez-Salas, R., additional, Tiwari, R.V., additional, Zhu, Y., additional, Dias dos Santos, C.P., additional, Dong, B., additional, Pan, J., additional, Chan, A., additional, Woon, D., additional, Kulkarni, G., additional, Perlis, N., additional, Hamilton, R., additional, Klotz, L., additional, Wallis, C.J.D., additional, Macek, P., additional, Tay, K.J., additional, Toi, A., additional, Finelli, A., additional, Fleshner, N.E., additional, Cathelineau, X., additional, Van Der Kwast, T.H., additional, Xue, W., additional, and Zlotta, A.R., additional

Published
2024
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2. A randomized Phase 3 trial of Metformin in patients initiating androgen deprivation therapy as PRevention and Intervention of MEtabolic syndrome: The PRIME Study

Author

Elangovan, A., primary, Eigl, B.J., additional, Ghosh, S., additional, Kim, J., additional, Thoms, J., additional, Bouchard, M., additional, Peacock, M., additional, Fleshner, N., additional, Campbell, H., additional, Vigneault, E., additional, Vincent, F., additional, So, A., additional, Cury, F., additional, Quon, H., additional, Carlson, R., additional, Lambert, C., additional, Klotz, L., additional, Chi, K., additional, Brundage, M., additional, Pollak, M., additional, and Usmani, N., additional

Published
2023
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3. Abstract No. 9 ▪ FEATURED ABSTRACT Pivotal Study of Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation (TULSA) of the Prostate: 4-year Follow-up

Author

Raman, S., primary, Arora, S., additional, Macura, K., additional, Oto, A., additional, Futterer, J., additional, Staruch, R., additional, Tirkes, T., additional, Bonekamp, D., additional, Haider, M., additional, Cool, D., additional, Nandalur, K., additional, Nicolau, C., additional, Costa, D., additional, Persigehl, T., additional, Clarke, G., additional, Chin, J., additional, Klotz, L., additional, and Eggener, S., additional

Published
2023
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4. Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA

Author

Kleinehr, J., primary, Daniel, K., additional, Günl, F., additional, Janowski, J., additional, Brunotte, L., additional, Liebmann, M., additional, Behrens, M., additional, Gerdemann, A., additional, Klotz, L., additional, Esselen, M., additional, Humpf, H.-U., additional, Ludwig, S., additional, and Hrincius, E. R., additional

Published
2022
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6. Cytoreductive surgery and hyperthermic chemoperfusion for malignant pleural mesothelioma within a multimodal treatment approach – a multicenter study in Germany

Author

Klotz, L, additional, Zimmermann, J, additional, Müller, K, additional, Hassan, M, additional, Kovacs, J, additional, Koller, M, additional, Schmid, S, additional, Huppertz, G, additional, Markowiak, T, additional, Passlick, B, additional, Winter, H, additional, Hofmann, H-S, additional, Hatz, R, additional, Eichhorn, M, additional, and Ried, M, additional

Published
2022
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8. Abstract No. 111 ▪ FEATURED ABSTRACT Pivotal trial of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: three-year follow-up

Author

Raman, S., primary, Arora, S., additional, Macura, K., additional, Oto, A., additional, Fütterer, J., additional, Staruch, R., additional, Tirkes, T., additional, Bonekamp, D., additional, Haider, M., additional, Cool, D., additional, Nandalur, K., additional, Nicolau, C., additional, Costa, D., additional, Persigehl, T., additional, Beserra, A., additional, Chin, J., additional, Klotz, L., additional, and Eggener, S., additional

Published
2022
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9. Focal laser ablation as clinical treatment of prostate cancer: report from a Delphi consensus project

Author

van Luijtelaar, A, Greenwood, BM, Ahmed, HU, Barqawi, AB, Barret, E, Bomers, JGR, Brausi, MA, Choyke, PL, Cooperberg, MR, Eggener, S, Feller, JF, Frauscher, F, George, AK, Hindley, RG, Jenniskens, SFM, Klotz, L, Kovacs, G, Lindner, U, Loeb, S, Margolis, DJ, Marks, LS, May, S, Mcclure, TD, Montironi, R, Nour, SG, Oto, A, Polascik, TJ, Rastinehad, AR, De Reyke, TM, Reijnen, JS, de la Rosette, JJMCH, Sedelaar, JPM, Sperling, DS, Walser, EM, Ward, JF, Villers, A, Ghai, S, and Fütterer, JJ

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Biomedical Imaging, Prostate Cancer, Urologic Diseases, Clinical Research, Aging, Cancer, Delphi Technique, Humans, Laser Therapy, Male, Practice Guidelines as Topic, Prostatectomy, Prostatic Neoplasms, Laser focal therapy, Focal laser ablation, Prostate cancer, Consensus, Delphi, Urology & Nephrology, Clinical sciences
Abstract

PurposeTo define the role of focal laser ablation (FLA) as clinical treatment of prostate cancer (PCa) using the Delphi consensus method.MethodsA panel of international experts in the field of focal therapy (FT) in PCa conducted a collaborative consensus project using the Delphi method. Experts were invited to online questionnaires focusing on patient selection and treatment of PCa with FLA during four subsequent rounds. After each round, outcomes were displayed, and questionnaires were modified based on the comments provided by panelists. Results were finalized and discussed during face-to-face meetings.ResultsThirty-seven experts agreed to participate, and consensus was achieved on 39/43 topics. Clinically significant PCa (csPCa) was defined as any volume Grade Group 2 [Gleason score (GS) 3+4]. Focal therapy was specified as treatment of all csPCa and can be considered primary treatment as an alternative to radical treatment in carefully selected patients. In patients with intermediate-risk PCa (GS 3+4) as well as patients with MRI-visible and biopsy-confirmed local recurrence, FLA is optimal for targeted ablation of a specific magnetic resonance imaging (MRI)-visible focus. However, FLA should not be applied to candidates for active surveillance and close follow-up is required. Suitability for FLA is based on tumor volume, location to vital structures, GS, MRI-visibility, and biopsy confirmation.ConclusionFocal laser ablation is a promising technique for treatment of clinically localized PCa and should ideally be performed within approved clinical trials. So far, only few studies have reported on FLA and further validation with longer follow-up is mandatory before widespread clinical implementation is justified.

Published
2019

11. Experiments on transient growth of turbulent spots

Author

Klotz, L. and Wesfreid, J. E.

Subjects
Physics - Fluid Dynamics
Abstract

We present detailed experiments on transient growth of turbulent spots induced by external forcing in plane Couette-Poiseuille flow, which are studied in the framework of linear of transient growth. The experimental investigation is supplemented with full theoretical analysis. We compare quantitatively the experimental and theoretical results, including maximal gain and the time at which it occurs. We also present the limits of validity for the application of the linear theory at high amplitude perturbation and Reynolds number, showing experiments with self-sustained states., Comment: 12 pages, 9 figures

Published
2017
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12. Experimental investigation of flow behind a cube for moderate Reynolds numbers

Author

Klotz, L., Goujon-Durand, S., Rokicki, J., and Wesfreid, J. E.

Subjects
Physics - Fluid Dynamics
Abstract

The wake behind a cube with a face normal to the flow was investigated experimentally in a water tunnel using laser induced fluorescence visualisation (LIF) and particle image velocimetry (PIV) techniques. Measurements were carried out for moderate Reynolds numbers between 100 and 400 and in this range a sequence of two flow bifurcations was confirmed. Values for both onsets were determined in the framework of Landau`s instability model. The measured longitudinal vorticity was separated into three components corresponding to each of the identified regimes. It was shown that the vorticity associated with a basic flow regime originates from corners of the bluff body, in contrast to the two other contributions which are related to instability effects. The present experimental results are compared with numerical simulation carried out earlier by Saha (Phys. Fluids, vol. 16, 2004, pp. 1630-1646)., Comment: 27 pages, 17 figures

Published
2017
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13. A generalized Schur complement for non-negative operators on linear space

Author

Friedrich, J., Günther, M., and Klotz, L.

Subjects
Mathematics - Functional Analysis, 47A05, 47A07
Abstract

Extending the corresponding notion for matrices or bounded linear operators on a Hilbert space we define a generalized Schur complement for a non-negative linear operator mapping a linear space into its dual and derive some of its properties.

Published
2017
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14. Effect of 18F-DCFPyL PET/CT (=PSMA PET) on the management of patients with suspected limited residual/recurrent disease following radical prostatectomy: Results of a prospective, multicenter registry trial

Author

Chin, J., primary, Metser, U., additional, Zukotynski, K., additional, Mak, V., additional, Langer, D., additional, Maccrostie, P., additional, Finelli, A., additional, Kapoor, A., additional, Lavallee, L., additional, Klotz, L., additional, Hagerty, M., additional, Hildebrand, C., additional, and Bauman, G., additional

Published
2022
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17. Active surveillance for intermediate-risk prostate cancer.

Author

DallEra, M and Klotz, L

Subjects
Biomarkers, Tumor, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Male, Multimodal Imaging, Neoplasm Grading, Outcome Assessment, Health Care, Polymorphism, Single Nucleotide, Population Surveillance, Prostatic Neoplasms, Risk Assessment, Risk Factors
Abstract

BACKGROUND: Utilization of active surveillance (AS) for prostate cancer is increasing. Optimal selection criteria for this approach are undefined and questions remain on how best to expand inclusion beyond typical men with very low- or low-risk disease. We sought to review the current experience with AS for men with intermediate-risk featuresMethods:PubMed was queried for all relevant original publications describing outcomes for men with prostate cancer managed with AS. Outcomes for patients with intermediate-risk features as defined by the primary investigators were studied when available and compared with similar risk men undergoing immediate treatment. RESULTS: Cancer-specific survival for men managed initially with AS is similar to results published with immediate radical intervention. A total of five published AS series describe some outcomes for men with intermediate-risk features. Definitions of intermediate risk vary between studies. Men with Gleason 7 disease experience higher rates of clinical progression and are more likely to undergo treatment over time. Intermediate-risk men with Gleason 6 disease have similar outcomes to low-risk men. Men with Gleason 7 disease appear at higher risk for metastatic disease. Novel technologies including imaging and biomarkers may assist with patient selection and disease surveillance. CONCLUSIONS: The contemporary experiences of AS for men with intermediate-risk features suggest that although these men are at higher risk for eventual prostate-directed treatment, some are not significantly compromising chances for longer-term cure. Men with more than minimal Gleason pattern 4, however, must be carefully selected and surveyed for early signs of progression and may be at increased risk of metastases. Incorporating information from advanced imaging and biomarker technology will likely individualize future treatment decisions while improving overall surveillance strategies.

Published
2017

19. Reply by Authors

Author

Saad, F., primary, Fleshner, N., additional, Pickles, T., additional, Niazi, T., additional, Lukka, H., additional, Pouliot, F., additional, Martins, I., additional, and Klotz, L., additional

Published
2021
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21. The prevalence of cardiovascular disease and its risk factors among prostate cancer patients treated with and without androgen deprivation

Author

Pinthus, J., primary, Shayegan, B., additional, Klotz, L., additional, Siemens, R., additional, Luke, P., additional, Niazi, T., additional, Fradet, V., additional, Fradet, Y., additional, Duceppe, E., additional, Lavallee, L., additional, Mousavi, N., additional, Hamilton, R., additional, Brown, I., additional, Gopaul, D., additional, Violette, P., additional, Davis, M., additional, Mian, R., additional, Karampatos, S., additional, and Darryl, L., additional

Published
2020
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22. Evaluation of the contribution of extragonadal steroids to androgen receptor activity and to castration resistance development in recurrent prostate cancers after primary therapy

Author

Pouliot, F., primary, Rouleau, M., additional, Neveu, B., additional, Toren, P., additional, Morin, F., additional, Vélot, L., additional, Ding, K., additional, Caron, P., additional, Lacombe, L., additional, Lévesque, É., additional, Klotz, L., additional, and Guillemette, C., additional

Published
2020
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23. Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis

Author

Jarius, S., Aktas, O., Ayzenberg, I., Bellmann-Strobl, J., Berthele, A., Giglhuber, K., Häußler, V., Havla, J., Hellwig, K., Hümmert, M.W., Kleiter, I., Klotz, L., Krumbholz, M., Kümpfel, T., Paul, F., Ringelstein, M., Ruprecht, K., Senel, M., Stellmann, J.P., Bergh, F.T., Tumani, H., Wildemann, B., and Trebst, C.

Subjects
Function and Dysfunction of the Nervous System
Abstract

The term 'neuromyelitis optica spectrum disorders' (NMOSD) is used as an umbrella term that refers to aquaporin-4 immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica (NMO) and its formes frustes and to a number of closely related clinical syndromes without AQP4-IgG. NMOSD were originally considered subvariants of multiple sclerosis (MS) but are now widely recognized as disorders in their own right that are distinct from MS with regard to immunopathogenesis, clinical presentation, optimum treatment, and prognosis. In part 1 of this two-part article series, which ties in with our 2014 recommendations, the neuromyelitis optica study group (NEMOS) gives updated recommendations on the diagnosis and differential diagnosis of NMOSD. A key focus is on differentiating NMOSD from MS and from myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis (MOG-EM; also termed MOG antibody-associated disease, MOGAD), which shares significant similarity with NMOSD with regard to clinical and, partly, radiological presentation, but is a pathogenetically distinct disease. In part 2, we provide updated recommendations on the treatment of NMOSD, covering all newly approved drugs as well as established treatment options.

Published
2023

26. 3:45 PM Abstract No. 341 Pivotal study of magnetic resonance imaging–guided transurethral ultrasound ablation in men with localized prostate cancer: 12-month clinical and imaging outcomes

Author

Raman, S., primary, Futterer, J., additional, Oto, A., additional, Arora, S., additional, Tirkes, T., additional, Macura, K., additional, Bonekamp, D., additional, Haider, M., additional, Cool, D., additional, Nandalur, K., additional, Nicolau, C., additional, Costa, D., additional, Persigehl, T., additional, Purysko, A., additional, Staruch, R., additional, Burtnyk, M., additional, Chin, J., additional, Klotz, L., additional, and Eggener, S., additional

Published
2020
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28. Characterization of the cardiac lymphatic vasculature

Author

Klotz, L. and Riley, P. R.

Subjects
618.92
Abstract

The lymphatic vasculature is a blind-ended network covering most tissues and organs of the body, crucial for tissue fluid homeostasis, immune surveillance and lipid adsorption from the gut. Recent evidence has proposed an entirely venous-derived mammalian lymphatic system. The major focus in the field has been on the systemic lymphatic vasculature, whilst organ-based lymphatics have been largely overlooked. In particular, the cardiac lymphatic vasculature has not been studied in great detail and the cellular origin of these vessels is yet to be determined. In contrast to the current dogma, the work presented in this thesis revealed that cardiac lymphatic vessels have a heterogeneous cellular origin. By utilizing multiple Cre transgenic mouse lines for lineage tracing studies and conditional Prox1 and Vegfr3 knockout mice, the data showed that the cardiac lymphatic vasculature is derived from both the blood and hemogenic endothelium during development. We hypothesized that the mechanisms underlying the development of the cardiac lymphatics might be reactivated following adult heart injury, therefore the innate cellular and molecular response of the cardiac lymphatic system to myocardial infarction (‘heart attack’) was investigated. A significant upregulation of lymphatic genes as well as a physical expansion of the lymphatic network via lymphangiogenesis was observed. These results prompt the re-evaluation of a century-long debate on the origin of lymphatic vessels and emphasize the significance of focusing on organ-based lymphatics during development and under pathological conditions. Specifically in the heart, this will enable better understanding of how to modulate the innate inflammatory response to promote cardiac wound healing and repair following myocardial infarction.

Published
2014

29. Comparison of micro-ultrasound and multiparametric MRI imaging for prostate cancer: A multicentre prospective analysis

Author

Lughezzani, G., primary, Pereira, J.G., additional, Sánchez, A., additional, Staerman, F., additional, Cash, H., additional, Lopez, L., additional, Rouffilange, J., additional, Gaston, R., additional, Klein, E., additional, Abouassaly, R., additional, El-Shefai, A., additional, Klotz, L., additional, and Eure, G., additional

Published
2019
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30. Reply by Authors

Author

Salari, K., primary, Kuppermann, D., additional, Preston, M. A., additional, Dahl, D. M., additional, Barrisford, G. W., additional, Efstathiou, J. A., additional, Blute, M. L., additional, Vesprini, D., additional, Loblaw, A., additional, Zietman, A. L., additional, Klotz, L., additional, and Feldman, A. S., additional

Published
2019
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38. Immunophenotyping of cerebrospinal fluid cells in ischaemic stroke

Author

Schulte‐Mecklenbeck, A., primary, Kleffner, I., additional, Beuker, C., additional, Wirth, T., additional, Hartwig, M., additional, Schmidt‐Pogoda, A., additional, Klotz, L., additional, Hansen, W., additional, Wiendl, H., additional, Meuth, S. G., additional, Gross, C. C., additional, and Minnerup, J., additional

Published
2019
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40. Tumor-derived granulocyte chemotactic protein 2 cooperates with neutrophil proteinase 3 to drive lung adenocarcinoma

Author

Lamort, A, primary, Weiß, S, additional, Lillis, I, additional, Armenis, V, additional, Arendt, K, additional, Pepe, M, additional, Klotz, L, additional, Marazioti, A, additional, Spella, M, additional, Giopanou, I, additional, Ntaliarda, G, additional, Giotopoulou, G, additional, Lianou, M, additional, Oplopoiou, M, additional, Kauka, K, additional, Jenne, D, additional, and Stathopoulos, G, additional

Published
2018
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46. Apheresis therapies for NMOSD attacks: A retrospective study of 207 therapeutic interventions

Author

Kleiter, Ingo, Gahlen, Anna, Borisow, Nadja, Fischer, Katrin, Wernecke, Klaus-Dieter, Hellwig, Kerstin, Pache, Florence, Ruprecht, Klemens, Havla, Joachim, Kümpfel, Tania, Aktas, Orhan, Hartung, Hans-Peter, Ringelstein, Marius, Geis, Christian, Kleinschnitz, Christoph, Berthele, Achim, Hemmer, Bernhard, Angstwurm, Klemens, Stellmann, Jan-Patrick, Schuster, Simon, Stangel, Martin, Lauda, Florian, Tumani, Hayrettin, Mayer, Christoph, Krumbholz, Markus, Zeltner, Lena, Ziemann, Ulf, Linker, Ralf, Schwab, Matthias, Marziniak, Martin, Then Bergh, Florian, Hofstadt-van Oy, Ulrich, Neuhaus, Oliver, Zettl, Uwe K., Faiss, Jürgen, Wildemann, Brigitte, Paul, Friedemann, Jarius, Sven, Trebst, Corinna, Albrecht, P., Ayzenberg, I., Bayas, A., Bellmann-Strobl, J., Bischof, F., Bittner, S., Böttcher, T., Brettschneider, J., Buttmann, M., DSouza, M., Ettrich, B., Frank, B., Gass, A., Grothe, M., Guthke, K., Haarmann, A., Habedank, E., Hoffmann, F., Hoffmann, O., Hümmert, M.W., Junghans, J., Kaste, M., Kaulen, B., Kermer, P., Kern, P., Klotz, L., Köhler, W., Kolesilova, E., Korsen, M., Kowarik, M., Langel, S., Lee, D.H., Liebetrau, M., Luessi, F., Marouf, W., Meister, S., Melms, A., Metz, I., Münch, C., Niehaus, S., Pawlitzki, M., Pellkofer, H., Puhlmann, H.U., Pul, R., Retzlaf, N., Riedlinger, A., Rommer, P., Röpke, L., Rostásy, K., Rückriem, L., Ruschil, C., Schippling, S., Senel, M., Sieb, J.P., Sommer, C., Spreer, A., Steinbrecher, A., Stephanik, H., Stoppe, M., Süße, M., Tackenberg, B., Tünnerhoff, J., Veauthier, C., Walter, A., Wandinger, K.P., Warnke, C., Weber, M.S., Weissert, R., Wiendl, H., Wilke, C., Winkelmann, A., Yalachkov, Y., Young, K., Zentner, C., and Zipp, F.

Published
2018
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